Hamming

Instructions

Calculate the Hamming Distance between two DNA strands.

Your body is made up of cells that contain DNA. Those cells regularly wear out and need replacing, which they achieve by dividing into daughter cells. In fact, the average human body experiences about 10 quadrillion cell divisions in a lifetime!

When cells divide, their DNA replicates too. Sometimes during this process mistakes happen and single pieces of DNA get encoded with the incorrect information. If we compare two strands of DNA and count the differences between them we can see how many mistakes occurred. This is known as the "Hamming Distance".

We read DNA using the letters C,A,G and T. Two strands might look like this:

GAGCCTACTAACGGGAT
CATCGTAATGACGGCCT
^ ^ ^  ^ ^    ^^

They have 7 differences, and therefore the Hamming Distance is 7.

The Hamming Distance is useful for lots of things in science, not just biology, so it's a nice phrase to be familiar with :)

Implementation notes

The Hamming distance is only defined for sequences of equal length, so an attempt to calculate it between sequences of different lengths should not work.

Track Specific Notes

For scheme, you may want to look into one of error, assert, or raise.

Running and testing your solutions

From the command line

Simply type make chez if you're using ChezScheme or make guile if you're using GNU Guile. Sometimes the name for the scheme binary on your system will differ from the defaults. When this is the case, you'll need to tell make by running make chez chez=your-chez-binary or make guile guile=your-guile-binary.

From a REPL

• Enter (load "test.scm") at the repl prompt.
• Develop your solution in hamming.scm reloading as you go.
• Run (test) to check your solution.

Failed Test Cases

If some of the test cases fail, you should see the failing input and the expected output. The failing input is presented as a list because the tests call your solution by (apply hamming input-list). To learn more about apply see The Scheme Programming Language -- Chapter 5

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Source

The Calculating Point Mutations problem at Rosalind